Her mother Kris, 63, hyped a jaw-dropping announcement about the 23-year-old supermodel over the weekend and praised her for being so "brave" and "vulnerable".
Promising Kendall's story would help her young followers, she wrote on the micro-blogging site on Saturday: "I'm so proud of my darling @KendallJenner for being so brave and vulnerable.
"Seeing you share [your] most raw story in order to make a positive impact for so many people and help foster a positive dialogue is a testament to the incredible woman you've become.
She continued: "Make sure to watch Kendall’s Twitter on Sunday night to find out what I’m talking about and be prepared to be moved."
The momanger added the hashtags: "#bethechange #shareyourstory #changetheconversation #proudmom #finallyasolution #authenticity #mydaughterinspiresme #getready."
Yet, fans labelled the over-hyped announcement as a "pathetic cry for attention" after she was unveiled as the new spokesperson for the US skincare brand, which is part-owned by Nestle.
One fan wrote: "You're joking me. This is the "big announcement"? This is a pathetic cry for attention."
A Twitter user mused: "@KendallJenner's big announcement was shameless… 50% of teens struggle with acne and they have to deal with it without a 5 million dollar contract from proactive."
"I'm seriously fuming. I thought you was gonna give us a sob story about anxiety but even worse you telling us you get spots just like 99 percent of the world does," another penned.
A fourth wrote: "Kardashians & Jenners are officially the most annoying ppl to walk the planet. WTF WAS THAT KENDALL ANNOUNCEMENT? A proactiv ambassador nnnnnn" (sic).
While another shared: "@KendallJenner is a joke!! This is her big story? This is another promotion to make money. Shame on her."
In a sneak peek of what would become her advert, Kendall spoke candidly to the camera about connecting with her fanbase.
She said: "When I was 14, I couldn't reach as many people that I can now that I'm 22. Now I have this whole thing behind me, I can speak to so many people and be like: 'I can help you and it's OK.'
"I experience it, I'm very normal, I understand you, I can connect with you… I'm going to try and help" as "connect with Kendall, Jan 6" flashed up on the screen.
The skincare brand, which was invented by dermatologists Katie Rodan and Kathy Fields, previously credits Katy Perry and Justin Bieber as brand ambassadors.
However, the pair's 2012 TV campaign was struck down in the UK after advertising chief ruled the commercial as misleading.
The FDA, one of the United States federal executive departments, previously named the brand as one of several in the market which could cause "rare but serious" allergic reactions.
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