It was derby day disappointment for Spurs as they fell to a 4-2 defeat against Arsenal at the weekend, despite leading at the Emirates.
They host a Saints side who are languishing in the bottom three following a dreadful start to the season, with Mark Hughes fired on Monday after a run of one win in 14 games.
Ralph Hasenhuttl is the man charged with turning Southampton's fortunes around now and he will be watching from the stands at Wembley.
What time is kick-off?
THIS game is being held on Wednesday, December 5.
Kick-off at Wembley is at 8pm.
Last season Harry Kane hit a hat-trick as Saints were beaten 5-2 in this reverse fixture.
Is Tottenham vs Southampton on TV and can I live stream it?
SADLY this one isn't going to be broadcast on UK TV.
But here on SunSport we have you covered with our comprehensive LIVE BLOG, which gets going at 7.55pm.
What is the team news?
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