Both sides come into this midweek fixture on the back of victories, with the home side picking up a valuable three points away at Huddersfield on Saturday.
Palace were on a barren run of eight games without a win before the visit of Burnley at the weekend, where they were able to run out 2-0 winners.
The Eagles haven't won on this ground since 2013, when two Wilfried Zaha goals gave them victory in the Championship play-offs.
What time is kick-off?
THIS clash on the south coast is all set for Tuesday, December 4.
Kick-off at the Amex is at 7.45pm.
Last season the sides played out an ill-tempered 0-0 draw in this fixture.
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Is Brighton vs Crystal Palace on TV and can I live stream it?
UNFORTUNATELY this game isn't being broadcast live in the UK.
But you can follow all the action here on SunSport, where we will be running a comprehensive LIVE BLOG.
What is the team news?
BOTH Glenn Murray and Beram Kayal sat out the victory in West Yorkshire but look set to return to the side.
There might also be a place for Anthony Knockaert, whilst Dale Stephens is definitely out as he completes a three-game ban.
Palace have no new injury worries and could name an unchanged XI for the third-straight game.
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